U.S. Multicenter Clinical Trial of Corneal Collagen Crosslinking for Treatment of Corneal Ectasia after Refractive Surgery

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Corneal Collagen Crosslinking for Ectasia after Refractive Surgery.

The development of corneal ectasia has been recognized as a complication after LASIK since the first case report from Seiler and Quurke in the late 1990s. The clinical picture of iatrogenic corneal ectasia resembles that of progressive keratoconus with reduced corneal biomechanical strength, increasing central corneal steepness, irregular refractive errors, and decreasing visual acuity. Since t...

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Corneal thickness changes after corneal collagen crosslinking for keratoconus and corneal ectasia: one-year results.

PURPOSE To determine the changes in corneal thickness over time after corneal collagen crosslinking (CXL) for keratoconus and corneal ectasia. SETTING Cornea and refractive surgery subspecialty practice. DESIGN Prospective randomized controlled clinical trial. METHODS Corneal thickness at the apex, thinnest point, and pupil center were measured using Scheimpflug imaging (Pentacam) at base...

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Corneal topography indices after corneal collagen crosslinking for keratoconus and corneal ectasia: one-year results.

PURPOSE To evaluate changes in corneal topography indices after corneal collagen crosslinking (CXL) in patients with keratoconus and corneal ectasia and analyze associations of these changes with visual acuity. SETTING Cornea and refractive surgery subspecialty practice. DESIGN Prospective randomized controlled clinical trial. METHODS Corneal collagen crosslinking was performed in eyes wi...

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United States Multicenter Clinical Trial of Corneal Collagen Crosslinking for Keratoconus Treatment.

PURPOSE To evaluate the safety and efficacy of corneal collagen crosslinking (CXL) for the treatment of progressive keratoconus. DESIGN Prospective, randomized, multicenter, controlled clinical trial. PARTICIPANTS Patients with progressive keratoconus (n = 205). METHODS The treatment group underwent standard CXL and the sham control group received riboflavin alone without removal of the e...

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Intrastromal corneal ring segment implantation for ectasia after refractive surgery.

PURPOSE To evaluate the clinical outcomes of intrastromal corneal ring segment (ICRS) implantation to correct ectasia in eyes with prior refractive surgery. METHODS Forty-one eyes of 25 patients (13 men, 12 women; mean age, 28.66 years) with ectasia after refractive surgery [photorefractive keratectomy (PRK) or laser in situ keratomileusis (LASIK)] were included in a nonrandomized, retrospect...

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ژورنال

عنوان ژورنال: Ophthalmology

سال: 2017

ISSN: 0161-6420

DOI: 10.1016/j.ophtha.2017.05.036